Numb family proteins (NFPs), including Numb and Numblike (Numbl), are commonly known for their role as cell fate determinants for multiple types of progenitor cells, mainly due to their function as Notch inhibitors.Previous studies have shown that myocardial NFP double knockout (MDKO) hearts display an up-regulated Notch activation and various defe
Every year more interest is focused on high frequencies (HF) communications for remote sensing platforms due to their capacity to establish links of more than Mens Tank Tops 250 km without a line of sight and due to them being a low-cost alternative to satellite communications.In this article, we study the ionospheric ordinary and extraordinary wav
Therapeutic Area: ASCVD/CVD Risk Factors Background: Excessive bodyweight, often associated with dyslipidemia, may affect the pharmacology of drugs.Inclisiran, a small interfering RNA targeting PCSK9 hepatic mRNA, is an effective LDL-C lowering agent with twice-yearly PLUS EPA subcutaneous dosing (after the initial and 3-month doses).The aim of thi
Low antigen immunogenicity poses a significant challenge in vaccine development, often leading to inadequate immune responses and reduced vaccine efficacy.Therefore, the discovery of potent immune-enhancing adjuvants is crucial.STING (stimulator of interferon genes) agonists are a promising class of adjuvants which have been identified in various i
Tutu The main objective of this article is to explore the causes of household electricity poverty in Spain from an innovative perspective.Based on evidence of energy inequality across households with different income levels, a quantile regression approach was used to better capture the heterogeneity of determinants of energy poverty across differen